From SearchForAncestors.com:

George F. Titlow, was born in Uniontown, Pennsylvania, July 31, 1864. He was educated in the public schools of that city, and from early manhood has been interested in hotel management and ownership in Fayette county. His first hotel experience was gained at the Yough House, in Connellsville, Pennsylvania, of which he was clerk from 1886 to 1888. He then assumed the management of the Hotel Marietta, in the same town, continuing until 1889. He was a popular and successful landlord, and now gained an experience and developed an ambition to provide better hotel accommodations for his section, which until his advent had been avoided by the traveling public as much as possible. In 1890 he came to Uniontown and purchased the Jennings House, paying for it the largest price ever paid for a hotel in Fayette county, $40,000; later he bought the McClelland House, in Uniontown, rebuilt, remodeled and made it such an attractive profitable hotel property that in 1903 he sold it for $90,000.

In 1905 he was able to carry out a long cherished plan and give to Uniontown a first-class modern, spacious European hotel. He erected and opened for business in that year the Hotel Titlow, of one hundred rooms, built at a cost of $200,000, the largest, most costly hostelry in Fayette county, and the first to be operated on the European plan. The hotel is thoroughly modern, and under Mr. Titlow's able management has gained a state-wide reputation. It is the established headquarters of the influential coal, coke and steel men of the county who have such vast quantities of wealth invested in Fayette county, and also political headquarters for Southwestern Pennsylvania.